#一。总述：this program is used for HBV data analysis
# need more data to improve it, a HBV expert‘s help is necessary
#二.检查数据包括data include:
#（1）HBsAg,（hepatitis B surface antigen) 表面抗原；
#阳性判断被HBV感染标志之一，但阴性不能排除隐匿性HBV病毒
#(2)HBsAB,（hepatitis B surface antibody)HBV表面抗体
#（3）HBcAg,(Hepatitis B Core antigen) 核心抗原；
#（4）HBeAg, (Hepatitis B e antigen),e抗原
#(5)HBeAb ,(Hepatitis B e antibody) HBV的e抗体
#(6) HBV-preS1Ag
#2HBV-DNA
#3.肝功十二项
#4.血常规检测 （淋巴细胞，白细胞，中性线细胞）
#（1）白细胞：正常值（4-10）*10的9次方/L，如果增多--各种细菌感染，炎症，严重烧伤
#如果减少脾功能亢进，造血功能障碍，放射线，药物，化学毒素等引起骨髓抑制，疟疾，伤寒，
#病毒感染，副伤寒。
#（2）中性粒细胞（neutrophil）：正常值（0.1-1.5）*10的9次方/L.增高：细菌感染，炎症；
#降低：病毒性感染
#（3）淋巴细胞：正常值（0.8-4.0）*10的9次方/L，增高：百日咳，传染性单核细胞增多症，病毒感染，急性传染性淋巴细胞增多症，淋巴细胞性白血病；
#降低：免疫缺陷
#三.程序目的：
#(1)描述HBV性质
#（2）检测Occult hepatitis B virus 隐匿性HBV病毒
#（3）检测慢性HBV病毒chronic HBV
#（4）检测急性HBV病毒 acute HBV
#(4.1)大三阳检测---传染性强
#（4.2）小三阳检测--传染性弱
# (5)检测变异HBV病毒 mutated HBV
# (6)检测病毒恢复期 recovery period
#（7）传染方式
#(8)疫苗注射咨询
#（9）免疫耐受期检测
#四.单词
# incubation （传染病的）潜伏期
#onset 发病
#semen精液
#vaginal secretions阴道分泌物
#wound exudates伤口分泌物
#antigen 抗原
#antibody 抗体
def introduction_HBV():
print """(1)HBV is short for Hepatitis B virus.\n(2)HBV is a DNA virus.\n(3)HBV is a
species of the genus Orthohepadnavirus, which is likewise a part of the
Hepadnaviridaefamily of viruses.\n(4)HBV can causes the hepatitis B and other disease
.\n(5)The incubation period from the time of exposure to onset of symptoms is 6 weeks to 6 months.
\n(6）HBV is found in highest concentrations in blood and in lower concentrations
in other body fluids (e.g., semen, vaginal secretions, and wound exudates).
\n(7)more information:http://en.wikipedia.org/wiki/Hepatitis_B_virus \nhttp://www.chinacdc.
cn/jkzt/crb/bdxgy/yxbdxgy/201301/t20130106_75116.htm"""
def transimission_HBV():
print """(1)blood\n(2)sex\n(3)born by mother\n(4)damaged skin or mucous \n(5)body fluids\n(6)drug injection"""
#HBV_DNA阳性测试，如果大于10**3，表示阳性
def HBV_DNA_test(HBV_DNA_value):
if HBV_DNA_value>10**3:
HBV_DNA="p"
def detect_HBV(HBsAg):
#是否感染HBV
if HBsAg=="p":
detect_result=True
if HBsAg=="n":
detect_result=False
print "healthy,but need HBV_DNA test to check Occulthepatitis B virus or mutated HBV"
return detect_result
def contagious_level(HBeAg,HBV_DNA=""):
#HBV传染强度测试
if HBeAg=="p" and HBV_DNA=="p":
contagious_result="high"
#需要进一步验证
if HBeAg=="n":
contagious_result="low"
return contagious_result
def detect__Occulthepatitis_B_virus(HBsAg,HBV_DNA):
#逆隐性HBV病毒
if HBsAg=="n" and HBV_DNA=="p":
result_Occulthepatitis_B_virus=True
elif HBsAg=="n" and HBV_DNA=="n":
result_Occulthepatitis_B_virus=False
else:
print "consult a doctor"
return result_Occulthepatitis_B_virus
def detect__mutated_HBV():
#HBV病毒变异判断
print "HBeAg positive or negative?"
HBeAg=raw_input().lower()
print "HBeAb positive or negative?"
HBeAb=raw_input().lower()
print "HBV_DNA positive or negative?"
HBV_DNA=raw_input().lower()
if HBeAg=="negative" or HBeAg=="n" and HBeAb=="positive" or HBeAb=="p" and\
HBV_DNA=="positive" or HBV_DNA=="p":
print "mutated HBV infected"
print "you may need a longer time to cure"
def recover_HBV(HBsAg,HBsAb,HBeAg,HBeAb,HBcAb,HBV_DNA):
#免疫恢复期判断(以前感染过HBV)
if HBsAg=="n"and HBeAg=="n" and HBV_DNA=="n" and HBeAb=="p" and HBcAb=="p" and HBsAb=="p" :
print "congulation! you are in recovery period! and have antibody for HBV"
result_recover_HBV=True
elif HBsAg=="n"and HBeAg=="n" and HBV_DNA=="n" and HBeAb=="p" and HBcAb=="p" and HBsAb=="n":
print "congulation! you are in recovery period! but you have no antibody for HBV,\
you should better consult a doctor for HBV vaccine"
result_recover_HBV=True
else:
print "you need to consult a doctor"
return result_recover_HBV
def vaccine_consult():
#是否接受疫苗
if recover_HBV()==True:
print "enter the HBsAb number:"
HBsAb_number=input()
if HBsAb_number<10:
print "you are in low level of HBV protection,consult \
a doctor for HBV vaccine injection"
else:
print"you are safe from HBV, but be careful for mutated HBV"
def HBV_status(HBsAg="",HBsAb="",HBeAg="",HBeAb="",HBcAb="",HBV_DNA="",AST=0,ALT=0):
# chronic HBV 急性乙肝前期
if HBsAg=="p" and HBsAb=="n" and HBeAg=="p" and HBeAb=="n" and HBcAb=="n":
result= "maybe chronic HBV infection early period"
# chronic HBV 急性乙肝后期
if HBsAg=="p" and HBsAb=="n" and HBeAg=="n" and HBeAb=="n" and HBcAb=="n":
result= "maybe chronic HBV infection later period"
# 大三阳,传染性高
if HBsAg=="p" and HBsAb=="n" and HBeAg=="p" and HBeAb=="n" and HBcAb=="p":
result="maybe da_san_yang"
#小三阳,传染性小
if HBsAg=="p" and HBsAb=="n" and HBeAg=="n" and HBeAb=="p" and HBcAb=="p":
result=" maybe xiao_san_yang"
def AST_devide_ALT(AST,ALT):
#AST/ALT比值，比值越大，肝破坏越大
return float(AST)/ALT
def hepatitis_status():
#相对参考,肝受损程度
value_AST_devide_ALT=AST_devide_ALT(AST,ALT)
if value_AST_devide_ALT<1:
result_hepatitis_status="maybe acute hepatitis"
else:
result_hepatitis_status="maybe chronic hepatitis"
return result_hepatitis_status
def blood_test(WBC,lympha,neutrophil):
#测试仪器---血液细胞分析仪检验（不同测试仪器标准参数不一样）
#（1）白细胞：正常值（3.5-9.5）*10的9次方/L，如果增多--各种细菌感染，炎症，严重烧伤
#如果减少脾功能亢进，造血功能障碍，放射线，药物，化学毒素等引起骨髓抑制，疟疾，伤寒，
#病毒感染，副伤寒。
#（2）中性粒细胞（neutrophil）：正常值（0.1-1.5）*10的9次方/L.增高：细菌感染，炎症；
#降低：病毒性感染
#（3）淋巴细胞：正常值（0.8-4.0）*10的9次方/L，增高：百日咳，传染性单核细胞增多症，病毒感染，急性传染性淋巴细胞增多症，淋巴细胞性白血病；
#降低：免疫缺陷
if WBC<3.5*(10**9) or neutrophil<2.0*(10**9) or lympha>4.0*(10**9):
result__blood_test="maybe virus infection"
if WBC>9.5*(10**9) or neutrophil>1.5*(10**9):
result__blood_test="maybe bacteria infection"
return result__blood_test
#免疫耐受期 immune tolerence
def immune_tolerence(result_hepatitis_status,HBV_DNA,result_HBV_status):
if result_hepatitis_status=="maybe acute hepatitis",and HBV_DNA=="p",and \
result_HBV_status="maybe da_san_yang":
return True
#main()
def main():
#HBV_DNA_value
print "input HBV_DNA number:"
HBV_DNA_value=input()
#HBsAg
print "HBsAg positive or negative?"
HBsAg=raw_input().lower()
HBsAg=HBsAg[0]
#HBsAb
print "HBsAb positive or negative?"
HBsAb=raw_input().lower()
HBsAb=HBsAb[0]
#HBeAg
print "HBeAg positive or negative?"
HBeAg=raw_input().lower()
HBeAg=HBeAg[0]
#HBeAb
print "HBeAb positive or negative?"
HBeAb=raw_input().lower()
HBeAb=HBeAb[0]
#HBcAb
print "HBcAb positive or negative?"
HBcAb=raw_input().lower()
HBcAb=HBcAb[0]
#HBV_DNA
print "HBV_DNA positive or negative?"
HBV_DNA=raw_input().lower()
HBV_DNA=HBV_DNA[0]
#AST
print "enter the AST number:"
AST=input()
#ALT
print "enter the ALT number:"
ALT=input()
#WBC 白细胞
print "enter the WBC value:"
WBC=input()
#lymphatic cell 淋巴细胞
print "enter the lympha value:"
lympha=input()
#neutrophil 中性细胞
print "enter the neutrophil value:"
neutrophil=input()
result_hepatitis_status=hepatitis_status()
result_HBV_status=HBV_status()
# result_recover_HBV=recover_HBV()