首先上题目:
Human Gene Functions
Time Limit: 2000/1000 MS (Java/Others) Memory Limit: 65536/32768 K (Java/Others)
Total Submission(s): 2570 Accepted Submission(s): 1451
Problem Description
It is well known that a human gene can be considered as a sequence, consisting of four nucleotides, which are simply denoted by four letters, A, C, G, and T. Biologists have been interested in identifying human genes and determining their functions, because
these can be used to diagnose human diseases and to design new drugs for them.
A human gene can be identified through a series of time-consuming biological experiments, often with the help of computer programs. Once a sequence of a gene is obtained, the next job is to determine its function. One of the methods for biologists to use in
determining the function of a new gene sequence that they have just identified is to search a database with the new gene as a query. The database to be searched stores many gene sequences and their functions – many researchers have been submitting their genes
and functions to the database and the database is freely accessible through the Internet.
A database search will return a list of gene sequences from the database that are similar to the query gene. Biologists assume that sequence similarity often implies functional similarity. So, the function of the new gene might be one of the functions that
the genes from the list have. To exactly determine which one is the right one another series of biological experiments will be needed.
Your job is to make a program that compares two genes and determines their similarity as explained below. Your program may be used as a part of the database search if you can provide an efficient one.
Given two genes AGTGATG and GTTAG, how similar are they? One of the methods to measure the similarity of two genes is called alignment. In an alignment, spaces are inserted, if necessary, in appropriate positions of the genes to make them equally long and score
the resulting genes according to a scoring matrix.
For example, one space is inserted into AGTGATG to result in AGTGAT-G, and three spaces are inserted into GTTAG to result in –GT--TAG. A space is denoted by a minus sign (-). The two genes are now of equal length. These two strings are aligned:
AGTGAT-G
-GT--TAG
In this alignment, there are four matches, namely, G in the second position, T in the third, T in the sixth, and G in the eighth. Each pair of aligned characters is assigned a score according to the following scoring matrix.
* denotes that a space-space match is not allowed. The score of the alignment above is (-3)+5+5+(-2)+(-3)+5+(-3)+5=9.
Of course, many other alignments are possible. One is shown below (a different number of spaces are inserted into different positions):
AGTGATG
-GTTA-G
This alignment gives a score of (-3)+5+5+(-2)+5+(-1) +5=14. So, this one is better than the previous one. As a matter of fact, this one is optimal since no other alignment can have a higher score. So, it is said that the similarity of the two genes is 14.
Input
The input consists of T test cases. The number of test cases ) (T is given in the first line of the input. Each test case consists of two lines: each line contains an integer, the length of a gene, followed by a gene sequence. The length of each gene sequence
is at least one and does not exceed 100.
Output
The output should print the similarity of each test case, one per line.
Sample Input
2 7 AGTGATG 5 GTTAG 7 AGCTATT 9 AGCTTTAAA
Sample Output
14 21
题目的意思是:
给定两个字符串a,b;其中两个字符串中的字母两两对应都有一个权值,并且两个字符串可以任意添加空格,使得有更多的字符可以对应,例如Given two genes AGTGATG and GTTAG,可以写成
AGTGAT-G
-GT--TAG
这样的最终对应权值是The score of the alignment above is (-3)+5+5+(-2)+(-3)+5+(-3)+5=9.
也可以写成
AGTGATG
-GTTA-G
这样的对应权值之和是(-3)+5+5+(-2)+5+(-1) +5=14,因为空格的加入,可以有很多种不同的权值和,要求的是最大的权值和。
我们看到题首先想到的是LCS,最长公共子序列,下面给个最长公共子序列dp的图以便读者对比:
而对于当前题目就是LCS的变种,是一种带有权值的最长公共子序列,这个权值要求就是满足如下矩阵且使权值和最大:
与上LCS结果状态对比图如下所示:
转移方程就是:dp[i][j]=max(a,b,c);//三个值中的最大值,a,b,c分别由左上,左,上三个方向的值加一数得到;
a=dp[i-1][j-1]+m[s1[i]][s2[j]]; //m[x][y]指x和y对应的值,假如x=A,y=G,则m[x][y]=-2,若x=T,y=‘-‘,则m[x][y]=-1;
b=dp[i][j-1]+m[‘-‘][s2[j]];
c=dp[i-1][j]+m[s1[i][‘-‘];
下面给个C++代码参考:
#include<iostream> //#include<string> //#include<algorithm> //#include<cmath> //#include<vector> //#include<stack> //#include<iomanip> using namespace std; #define MAX 105 /*测试数据 */ int dp[105][105]; int m[5][5]={//行列顺序都为ACGT- {5,-1,-2,-1,-3}, {-1,5,-3,-2,-4}, {-2,-3,5,-2,-2}, {-1,-2,-2,5,-1}, {-3,-4,-2,-1,-100} }; int mymap( char x) { if(x=='A')return 0; if(x=='C')return 1; if(x=='G')return 2; if(x=='T')return 3; return 4; } int getmax(int a,int b,int c) { int mm=a; if(b>mm) mm=b; if(c>mm) mm=c; return mm; } int main() { int T,n1,n2; int j,i; char s1[105],s2[105]; cin>>T; while(T--) { cin>>n1>>s1+1; cin>>n2>>s2+1; dp[0][0]=0; s1[0]=s2[0]='-'; for(i=1;i<=n1;i++) dp[0][i]=dp[0][i-1]+m[4][mymap(s1[i])]; for(i=1;i<=n2;i++) dp[i][0]=dp[i-1][0]+m[mymap(s2[i])][4]; for(i=1;i<=n2;i++) for(j=1;j<=n1;j++) dp[i][j]=getmax((dp[i-1][j-1]+m[mymap(s2[i])][mymap(s1[j])]),dp[i-1][j]+m[mymap(s2[i])][4],dp[i][j-1]+m[4][mymap(s1[j])]); cout<<dp[n2][n1]<<endl; } return 0; }